ChloroquineV1, Main, Exploration, bibRecord, 003F50

Fatal myocarditis due to emetine hydrochloride

Identifieur interne : 003F50 ( Main/Exploration ); précédent : 003F49; suivant : 003F51

Fatal myocarditis due to emetine hydrochloride

Auteurs : Thomas H. Brem [États-Unis] ; Benjamin E. Konwaler [États-Unis]

Source :

American Heart Journal [ 0002-8703 ] ; 1955.

RBID : ISTEX:66E587D8778202C1B4E52F2E1986FD8EC9C5261E

English descriptors

Teeft :
- Abscess, Abscess cavity, Amebiasis, Amebic, Amebic abscess, Amebic liver abscess, Blood pressure, Brem, Cardiac, Chest wall, Chloroquine, Dyspnea, Electrocardiogram, Electrocardiographic, Emetine, Emetine hydrochloride, Emetine toxicity, Experimental animals, February, Heart rate, Hepatic, Hepatic amebiasis, Konwaler, Large quantities, Liver abscess, Myocarditis, Pathologic findings, Potential hazards, Right lung, Toxicity.

Abstract

Abstract: 1.1. Emetine hydrochloride when given in the usual therapeutic doses frequently produces definite but not dangerous effects on the heart.2.2. Individual tolerance to emetine toxicity is extremely variable. The human lethal dose appears to be about 20 mg./kg. of body weight.3.3. Long or frequently repeated courses of emetine may constitute a distinct hazard. An illustrative case of emetine-induced myocarditis with death and pathologic findings is described.4.4. Although chloroquine should replace emetine in the therapy of hepatic amebiasis, the latter will still be useful in other forms of extraintestinal amebiasis. The potential hazards of its use should therefore be recognized.

Url:

https://api.istex.fr/ark:/67375/6H6-F64GFTMZ-8/fulltext.pdf

DOI: 10.1016/0002-8703(55)90169-1

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: 000C39
to stream Istex, to step Curation: 000C39
to stream Istex, to step Checkpoint: 002C66
to stream Main, to step Merge: 004038
to stream Main, to step Curation: 003F50

Le document en format XML

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<front><div type="abstract" xml:lang="en">Abstract: 1.1. Emetine hydrochloride when given in the usual therapeutic doses frequently produces definite but not dangerous effects on the heart.2.2. Individual tolerance to emetine toxicity is extremely variable. The human lethal dose appears to be about 20 mg./kg. of body weight.3.3. Long or frequently repeated courses of emetine may constitute a distinct hazard. An illustrative case of emetine-induced myocarditis with death and pathologic findings is described.4.4. Although chloroquine should replace emetine in the therapy of hepatic amebiasis, the latter will still be useful in other forms of extraintestinal amebiasis. The potential hazards of its use should therefore be recognized.</div>
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Fatal myocarditis due to emetine hydrochloride

Fatal myocarditis due to emetine hydrochloride

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri